Mechanism of Valeriana officinalis L. extract improving atherosclerosis by regulating PGC-1α/Sirt3/Epac1 pathway

ObjectiveTo investigate the protective effect of the of Valeriana officinalis L. extract on mitochondrial injury in AS mice and the underlying mechanism.MethodsFirstly, Ultra-High performance liquid chromatography-quadrupole time-of-flight mass spectrometer (UPLC / Q-TOF-MS) was proposed to explore...

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Hauptverfasser:	Bo Yao, Jingzhuo Ma, Qingzhi Ran, Hengwen Chen, Xuanhui He
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2024-11-01
Schriftenreihe:	Frontiers in Pharmacology
Schlagworte:	Valeriana officinalis L. extract atherosclerosis PGC-1α/Sirt3/Epac1 pathway mitochondrial damage traditional Chinese medicine
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1483518/full
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