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Mechanism of Valeriana officinalis L. extract improving atherosclerosis by regulating PGC-1α/Sirt3/Epac1 pathway

ObjectiveTo investigate the protective effect of the of Valeriana officinalis L. extract on mitochondrial injury in AS mice and the underlying mechanism.MethodsFirstly, Ultra-High performance liquid chromatography-quadrupole time-of-flight mass spectrometer (UPLC / Q-TOF-MS) was proposed to explore...

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Principais autores: Bo Yao, Jingzhuo Ma, Qingzhi Ran, Hengwen Chen, Xuanhui He
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-11-01
Serier:Frontiers in Pharmacology
Fag:
Valeriana officinalis L. extract
atherosclerosis
PGC-1α/Sirt3/Epac1 pathway
mitochondrial damage
traditional Chinese medicine
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2024.1483518/full
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