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IGFBP3 induces PD-L1 expression to promote glioblastoma immune evasion

Abstract Background Glioblastoma (GBM) characterized by immune escape is the most malignant primary brain tumors, which has strong immunosuppressive effect. Programmed death ligand-1 (PD-L1) is a recognized immunosuppressive member on the surface of tumor cells, and plays a crucial role in immune ev...

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Principais autores: Leilei Zhao, Yudi Wang, Peizheng Mu, Xuehua Zhang, Ruomei Qi, Yurui Zhang, He Zhang, Xiao Zhu, Zhouyan Dong, Yucui Dong
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-02-01
Serier:Cancer Cell International
Fag:
Glioblastoma
IGFBP3
PD-L1
JAK2
STAT3
Target therapy
Online adgang:https://doi.org/10.1186/s12935-024-03234-3
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