Renal Cell Carcinoma (RCC) Tumors Display Large Expansion of Double Positive (DP) CD4+CD8+ T Cells With Expression of Exhaustion Markers

Checkpoint inhibitors target the inhibitory receptors expressed by tumor-infiltrating T cells in order to reinvigorate an anti-tumor immune response. Therefore, understanding T cell composition and phenotype in human tumors is crucial. We analyzed by flow cytometry tumor-infiltrating lymphocytes (TI...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Laurence C. Menard, Paul Fischer, Bijal Kakrecha, Peter S. Linsley, Erik Wambre, Maochang C. Liu, Blake J. Rust, Deborah Lee, Becky Penhallow, Nataly Manjarrez Orduno, Steven G. Nadler
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-11-01
Colecção:	Frontiers in Immunology
Assuntos:	renal cell carcinoma (RCC) CD4+CD8+ T cells T cell dysfunction TIM-3 PD-1 clonal expansion
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2018.02728/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!