Renal Cell Carcinoma (RCC) Tumors Display Large Expansion of Double Positive (DP) CD4+CD8+ T Cells With Expression of Exhaustion Markers

Checkpoint inhibitors target the inhibitory receptors expressed by tumor-infiltrating T cells in order to reinvigorate an anti-tumor immune response. Therefore, understanding T cell composition and phenotype in human tumors is crucial. We analyzed by flow cytometry tumor-infiltrating lymphocytes (TI...

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Главные авторы:	Laurence C. Menard, Paul Fischer, Bijal Kakrecha, Peter S. Linsley, Erik Wambre, Maochang C. Liu, Blake J. Rust, Deborah Lee, Becky Penhallow, Nataly Manjarrez Orduno, Steven G. Nadler
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2018-11-01
Серии:	Frontiers in Immunology
Предметы:	renal cell carcinoma (RCC) CD4+CD8+ T cells T cell dysfunction TIM-3 PD-1 clonal expansion
Online-ссылка:	https://www.frontiersin.org/article/10.3389/fimmu.2018.02728/full
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