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Simultaneous determination of 9 CYP450 enzymes in human liver microsomes using LC-MS/MS

Objective To develop a liquid chromatography with tandem mass spectrometry (LC-MS/MS) to simultaneously detect the activities of 9 CYP450 enzymes in human liver microsomes in order to anticipate the possibility of drug-drug interactions. Methods Nine different enzyme substrates were used as probes t...

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Principais autores: SHI Zhongbo, ZHAO Dezhang, JIANG Junhao, XIE Baogang, LI Yan, YU Chao
Formato: Artigo
Idioma:Chinês
Publicado em: Editorial Office of Journal of Third Military Medical University 2021-02-01
coleção:Di-san junyi daxue xuebao
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Acesso em linha:https://aammt.tmmu.edu.cn/Upload/rhtml/202008230.htm
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