Assessments of CYP‑inhibition‑based drug–drug interaction between vonoprazan and poziotinib in vitro and in vivo

AbstractContext Poziotinib and vonoprazan are two drugs mainly metabolized by CYP3A4. However, the drug-drug interaction between them is unknown.Objective To study the interaction mechanism and pharmacokinetics of poziotinib on vonoprazan.Materials and methods In vitro experiments were performed wit...

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Detalhes bibliográficos

Principais autores:	Shan Zhou, Fang-Ling Zhao, Shuang-Hu Wang, Yi-Ran Wang, Yun Hong, Quan Zhou, Pei-Wu Geng, Qing-Feng Luo, Jian-Ping Cai, Da-Peng Dai
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2023-12-01
Colecção:	Pharmaceutical Biology
Assuntos:	CYP3A4 pharmacokinetics drug inhibition UPLC-MS/MS
Acesso em linha:	https://www.tandfonline.com/doi/10.1080/13880209.2023.2173253
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