Ribosome engineering of Myxococcus xanthus for enhancing the heterologous production of epothilones

Abstract Background Ribosome engineering is a semi-empirical technique used to select antibiotic-resistant mutants that exhibit altered secondary metabolism. This method has been demonstrated to effectively select mutants with enhanced synthesis of natural products in many bacterial species, includi...

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Principais autores:	Xu Kang, Xiao-ran Yue, Chen-xi Wang, Jia-rui Wang, Jun-ning Zhao, Zhao-peng Yang, Qin-ke Fu, Chang-sheng Wu, Wei Hu, Yue-zhong Li, Xin-jing Yue
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2024-12-01
Series:	Microbial Cell Factories
Assuntos:	Ribosome engineering Myxococcus xanthus Secondary metabolism Production of epothilones Metabolic interference
Acceso en liña:	https://doi.org/10.1186/s12934-024-02627-3
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