Ribosome engineering of Myxococcus xanthus for enhancing the heterologous production of epothilones

Abstract Background Ribosome engineering is a semi-empirical technique used to select antibiotic-resistant mutants that exhibit altered secondary metabolism. This method has been demonstrated to effectively select mutants with enhanced synthesis of natural products in many bacterial species, includi...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Xu Kang, Xiao-ran Yue, Chen-xi Wang, Jia-rui Wang, Jun-ning Zhao, Zhao-peng Yang, Qin-ke Fu, Chang-sheng Wu, Wei Hu, Yue-zhong Li, Xin-jing Yue
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-12-01
Schriftenreihe:	Microbial Cell Factories
Schlagworte:	Ribosome engineering Myxococcus xanthus Secondary metabolism Production of epothilones Metabolic interference
Online-Zugang:	https://doi.org/10.1186/s12934-024-02627-3
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