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SIRT1 regulates glycolysis and angiogenesis of ovarian cancer through β-catenin/c-Myc/PKM2, and its mechanism in chemotherapy resistance

BackgroundThe purpose of this study is to explore the molecular mechanism of SIRT1 regulating chemotherapy resistance.MethodsExpression level of SIRT1 in ovarian cancer cell lines SKOV3, SKOV3/DDP (cisplatin-resistant cell line) and normal ovarian epithelial cell line IOSE80 was detected. Through th...

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Principais autores: Chengju Zhang, Hu Wang, Yu Zhou, Deng He, Tiantian Feng, Xi Wang, Shangqi Ni, Juan Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-03-01
coleção:Frontiers in Oncology
Assuntos:
angiogenesis
chemotherapy resistance
glycolysis
ovarian cancer
SIRT1
β-catenin
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2026.1762850/full
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