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Identification of tyrosine brominated extracellular matrix proteins in normal and fibrotic lung tissues

Peroxidasin (PXDN) is a secreted heme peroxidase that catalyzes the oxidative crosslinking of collagen IV within the extracellular matrix (ECM) via intermediate hypobromous acid (HOBr) synthesis from hydrogen peroxide and bromide, but recent findings have also suggested alternative ECM protein modif...

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Principais autores: Litiele Cezar Cruz, Aida Habibovic, Bianca Dempsey, Mariana P. Massafera, Yvonne M.W. Janssen-Heininger, Miao-chong Joy Lin, Evan T. Hoffman, Daniel J. Weiss, Steven K. Huang, Albert van der Vliet, Flavia C. Meotti
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-05-01
Colecção:Redox Biology
Assuntos:
Peroxidasin
Hypobromous acid
Bromotyrosine
Laminin
Collagen
Tubulointerstitial nephritis antigen-like 1
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213231724000788
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