Cellular 5′-3′ mRNA Exoribonuclease XRN1 Inhibits Interferon Beta Activation and Facilitates Influenza A Virus Replication

ABSTRACT Cellular 5′-3′ exoribonuclease 1 (XRN1) is best known for its role as a decay factor, which by degrading 5′ monophosphate RNA after the decapping of DCP2 in P-bodies (PBs) in Drosophila, yeast, and mammals. XRN1 has been shown to degrade host antiviral mRNAs following the influenza A virus...

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Principais autores:	Yen-Chin Liu, Bobo Wing-Yee Mok, Pui Wang, Rei-Lin Kuo, Honglin Chen, Shin-Ru Shih
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2021-08-01
coleção:	mBio
Assuntos:	influenza virus 5′-3′ mRNA degradation XRN1 nonstructural protein 1 NS1 interferon beta
Acesso em linha:	https://journals.asm.org/doi/10.1128/mBio.00945-21
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