N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer’s disease

Abstract Background N6-methyladenosine (m6A) modification is known to impact many aspects of RNA metabolism, including mRNA stability and translation, and is highly prevalent in the brain. Results We show that m6A modification displays temporal and spatial dynamics during neurodevelopment and aging....

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Hlavní autoři:	Andrew M. Shafik, Feiran Zhang, Zhenxing Guo, Qing Dai, Kinga Pajdzik, Yangping Li, Yunhee Kang, Bing Yao, Hao Wu, Chuan He, Emily G. Allen, Ranhui Duan, Peng Jin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2021-01-01
Edice:	Genome Biology
Témata:	Epitranscriptomics m6A Neurodevelopment Aging Alzheimer’s Regulation of mRNA levels
On-line přístup:	https://doi.org/10.1186/s13059-020-02249-z
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