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Pan-coronavirus fusion inhibitors possess potent inhibitory activity against HIV-1, HIV-2, and simian immunodeficiency virus

EK1 peptide is a membrane fusion inhibitor with broad-spectrum activity against human coronaviruses (CoVs). In the outbreak of COVID-19, we generated a lipopeptide EK1V1 by modifying EK1 with cholesterol, which exhibited significantly improved antiviral activity. In this study, we surprisingly found...

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Principais autores: Danwei Yu, Yuanmei Zhu, Hongxia Yan, Tong Wu, Huihui Chong, Yuxian He
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2021-01-01
Serier:Emerging Microbes and Infections
Fag:
Coronavirus
SARS-CoV-2
HIV-1
fusion inhibitor
lipopeptide
Online adgang:https://www.tandfonline.com/doi/10.1080/22221751.2021.1917309
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