Pan-coronavirus fusion inhibitors possess potent inhibitory activity against HIV-1, HIV-2, and simian immunodeficiency virus

EK1 peptide is a membrane fusion inhibitor with broad-spectrum activity against human coronaviruses (CoVs). In the outbreak of COVID-19, we generated a lipopeptide EK1V1 by modifying EK1 with cholesterol, which exhibited significantly improved antiviral activity. In this study, we surprisingly found...

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Hlavní autoři:	Danwei Yu, Yuanmei Zhu, Hongxia Yan, Tong Wu, Huihui Chong, Yuxian He
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2021-01-01
Edice:	Emerging Microbes and Infections
Témata:	Coronavirus SARS-CoV-2 HIV-1 fusion inhibitor lipopeptide
On-line přístup:	https://www.tandfonline.com/doi/10.1080/22221751.2021.1917309
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