Stress‐response balance drives the evolution of a network module and its host genome

Abstract Stress response genes and their regulators form networks that underlie drug resistance. These networks often have an inherent tradeoff: their expression is costly in the absence of stress, but beneficial in stress. They can quickly emerge in the genomes of infectious microbes and cancer cel...

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Hlavní autoři:	Caleb González, Joe Christian J Ray, Michael Manhart, Rhys M Adams, Dmitry Nevozhay, Alexandre V Morozov, Gábor Balázsi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer Nature 2015-08-01
Edice:	Molecular Systems Biology
Témata:	drug resistance experimental evolution positive feedback synthetic gene circuit tradeoff
On-line přístup:	https://doi.org/10.15252/msb.20156185
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