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The PRMT5-LSD1 axis confers Slug dual transcriptional activities and promotes breast cancer progression

Abstract Background Downregulation of epithelial markers and upregulation of mesenchymal markers are the characteristics of the epithelial to mesenchymal transition (EMT) program, which provides the metastatic advantage of breast cancer. However, the mechanism underlying the switch of EMT markers re...

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Principais autores: Jianchao Zhang, Xiaokai Fan, Yunfan Zhou, Liang Chen, Hai Rao
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2022-06-01
Series:Journal of Experimental & Clinical Cancer Research
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Acceso en liña:https://doi.org/10.1186/s13046-022-02400-7
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