Cross-genus phage design through branching domain and conserved peptide interactions

Abstract Background Branched receptor-binding protein (RBP) systems enable bacteriophages to broaden their host range through the incorporation of two or more RBPs. Using the Klebsiella podophages KP32, K11, and KP34 as model systems, we experimentally validated the interaction between the branching...

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Detalles Bibliográficos

Principais autores:	Agnieszka Latka, Dorien Dams, Lennert Scholiers, Britt Van Mieghem, Zuzanna Drulis-Kawa, Yves Briers
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2026-05-01
Series:	Journal of Biological Engineering
Assuntos:	Klebsiella phage Host range Receptor-binding protein Depolymerase Tailspike Branching domain
Acceso en liña:	https://doi.org/10.1186/s13036-026-00682-5
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