Cross-genus phage design through branching domain and conserved peptide interactions

Abstract Background Branched receptor-binding protein (RBP) systems enable bacteriophages to broaden their host range through the incorporation of two or more RBPs. Using the Klebsiella podophages KP32, K11, and KP34 as model systems, we experimentally validated the interaction between the branching...

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Үндсэн зохиолчид:	Agnieszka Latka, Dorien Dams, Lennert Scholiers, Britt Van Mieghem, Zuzanna Drulis-Kawa, Yves Briers
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2026-05-01
Цуврал:	Journal of Biological Engineering
Нөхцлүүд:	Klebsiella phage Host range Receptor-binding protein Depolymerase Tailspike Branching domain
Онлайн хандалт:	https://doi.org/10.1186/s13036-026-00682-5
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!