A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity

The assembly of the splicesome involves several distinct stages that require the sequential action of DExD/H-box RNA helicases. Here, the authors uncover a new intermediate, the pre-B complex, that accumulates in the presence of an inactive form of the DEAD-box protein Prp28.

Opis bibliograficzny

Główni autorzy:	Carsten Boesler, Norbert Rigo, Maria M. Anokhina, Marcel J. Tauchert, Dmitry E. Agafonov, Berthold Kastner, Henning Urlaub, Ralf Ficner, Cindy L. Will, Reinhard Lührmann
Format:	Artigo
Język:	Inglês
Wydane:	Nature Portfolio 2016-07-01
Seria:	Nature Communications
Dostęp online:	https://doi.org/10.1038/ncomms11997
Etykiety:	Dodaj etykietę Nie ma etykietki, Dołącz pierwszą etykiete!