Deep learning-assisted discovery of a potent and cell-active inhibitor of RNA N6-methyladenosine recognition protein YTHDC2

Abstract YTHDC2, a unique YTH-domain-containing protein that recognizes N6-methyladenosine (m6A) on RNA, plays critical roles in diverse pathological processes and represents a promising therapeutic target. Despite its potential, no potent small-molecule inhibitors have been reported to date. To bri...

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Bibliografiske detaljer

Principais autores:	Zhenyu Yang, Weining Sun, Qiao Huang, Yueyue Li, Meng Yuan, Yu Yang, Heng Zhao, Zheyi Liu, Xiaoxi Zeng, Fangjun Wang, Yuanyuan Jiang, Yi Zhao, Runsheng Chen
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2026-01-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-025-65542-0
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