Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors

Fatty Acid Amide Hydrolase (FAAH) is a serine hydrolase that plays a key role in controlling endogenous levels of endocannabinoids. FAAH inhibition is considered a powerful approach to enhance the endocannabinoid signalling, and therefore it has been largely studied as a potential target for the tre...

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Detalhes bibliográficos

Principais autores:	Alessandro Deplano, Mariateresa Cipriano, Federica Moraca, Ettore Novellino, Bruno Catalanotti, Christopher J. Fowler, Valentina Onnis
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2019-01-01
Colecção:	Journal of Enzyme Inhibition and Medicinal Chemistry
Assuntos:	ibuprofen amides faah inhibition fatty acid amide hydrolase endocannabinoids induced fit docking
Acesso em linha:	http://dx.doi.org/10.1080/14756366.2018.1532418
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