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Molecular basis underpinning MR1 allomorph recognition by an MR1-restricted T cell receptor

IntroductionThe MHC-class-I-related molecule MR1 presents small metabolites of microbial and self-origin to T cells bearing semi-invariant or variant T cell receptors. One such T cell receptor, MC.7.G5, was previously shown to confer broad MR1-restricted reactivity to tumor cells but not normal cell...

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Principais autores: Richard J. Suckling, Cevriye Pamukcu, Robert Alan Simmons, Daniel Fonseca, Emma Grant, Rory Harrison, Saher A. Shaikh, Rahul C. Khanolkar, Hemza Ghadbane, Andrew Creese, Miriam Hock, Thomas G. Gligoris, Marco Lepore, Vijaykumar Karuppiah, Mariolina Salio
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-03-01
coleção:Frontiers in Immunology
Assuntos:
MR1
cancer
metabolites
MAIT
TCR
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1547664/full
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