Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach

Mycobacterium phenotypic hits are a good reservoir for new chemotypes for the treatment of tuberculosis. However, the absence of defined molecular targets and modes of action could lead to failure in drug development. Therefore, a combination of ligand-based and structure-based chemogenomic approach...

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Principais autores:	Grace Mugumbate, Vitor Mendes, Michal Blaszczyk, Mohamad Sabbah, George Papadatos, Joel Lelievre, Lluis Ballell, David Barros, Chris Abell, Tom L. Blundell, John P. Overington
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2017-09-01
coleção:	Frontiers in Pharmacology
Assuntos:	Mycobacterium tuberculosis phenotypic hits target identification drug resistance EthR InhA
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fphar.2017.00681/full
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