Aptamer-based approaches for sensitive detection and epitope mapping of SARS-CoV-2 spike protein

The SARS-CoV-2 spike (S) protein, crucial for viral entry, remains a key target for diagnostics and therapeutics amid evolving variants. Here, we describe the selection and characterization of novel DNA aptamers targeting the S1 subunit, including the Omicron strain, via systematic evolution of liga...

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Bibliografske podrobnosti

Principais autores:	Suttinee Poolsup, Elnaz Yaghoobi, Aliaksandra Radchanka, Nandanee Mulloo, Spencer Uguccioni, John Paul Pezacki, Abdullah Khraibah, Aasha Jawad, Gurcharan K. Uppal, Yuxuan Gu, Benjamin Patrick Lapointe, Nico Hüttmann, Zoran Minic, Polina V. Artyushenko, Irina A. Shchugoreva, Anastasia V. Rogova, Felix N. Tomilin, Dmitry Morozov, Anna S. Kichkailo, Olga S. Kolovskaya, Maxim V. Berezovski
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2026-03-01
Serija:	Molecular Therapy: Nucleic Acids
Teme:	MT: oligonucleotides: diagnostics and biosensors DNA aptamers to SARS-CoV-2 S1 subunit COVID-19 diagnostics protein binding epitopes proximity ligation of aptamers biolayer interferometry assay
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2162253125003440
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