CRISPR/Cas9 engineered and whole-genome characterized KIT D816V-mutant human iPSC lines

We report on the generation of human induced pluripotent stem cell (iPSC) lines, BIHi005-A-86 and BIHi005-A-87, carrying the KIT D816V mutation associated with Indolent Systemic Mastocytosis (ISM). To overcome the confounding genetic backgrounds of existing leukemic models, we introduced this gain-o...

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Autores principales:	Yanyan Luo, Valeria Fernandez Vallone, Eric Blanc, Duncan C. Miller, Jiajun He, Harald Stachelscheid, Dieter Beule, Jörg Scheffel, Frank Siebenhaar
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2026-06-01
Colección:	Stem Cell Research
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S1873506126000711
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