Time‑resolved multi-omic analysis of paclitaxel exposure in human iPSC‑derived sensory neurons unveils mechanisms of chemotherapy‑induced peripheral neuropathy

Abstract The microtubule-stabilizing drug paclitaxel remains the standard of care for various solid malignancies but frequently leads to chemotherapy-induced peripheral neuropathy (CIPN). CIPN is a leading cause for premature treatment termination and a significantly reduced quality of life in long-...

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主要な著者:	Christian Schinke, Smilla K. Maierhof, Lois Hew, Valeria Fernandez Vallone, Silke Frahm, Narasimha Swamy Telugu, Sebastian Diecke, Andranik Ivanov, Richard Kovács, Dieter Beule, Marieluise Kirchner, Philipp Mertins, Ulrike Brüning, Jennifer A. Kirwan, Harald Stachelscheid, Matthias Endres, Petra Huehnchen, Wolfgang Boehmerle
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Publishing Group 2026-02-01
シリーズ:	Cell Death and Disease
オンライン･アクセス:	https://doi.org/10.1038/s41419-026-08445-2
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