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O-GlcNAc impacts mitophagy via the PINK1-dependent pathway

BackgroundThe accumulation of dysfunctional mitochondria is an early feature of Alzheimer’s disease (AD). The impaired turnover of damaged mitochondria increases reactive oxygen species production and lowers ATP generation, leading to cellular toxicity and neurodegeneration. Interestingly, AD exhibi...

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Autori principali: Ibtihal M. Alghusen, Marisa S. Carman, Heather M. Wilkins, Taylor A. Strope, Caleb Gimore, Halyna Fedosyuk, Jad Shawa, Sophiya John Ephrame, Aspin R. Denson, Xiaowan Wang, Russell H. Swerdlow, Chad Slawson
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2024-08-01
Serie:Frontiers in Aging Neuroscience
Soggetti:
O-GlcNAc
mitophagy
PTEN-induced kinase-1
Alzheimer’s disease
OGT
Accesso online:https://www.frontiersin.org/articles/10.3389/fnagi.2024.1387931/full
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