Real-Time Positron Emission Tomography Evaluation of Topotecan Brain Kinetics after Ultrasound-Mediated Blood–Brain Barrier Permeability

Glioblastoma (GBM) is the most common primary adult brain malignancy with an extremely poor prognosis and a median survival of fewer than two years. A key reason for this high mortality is that the blood–brain barrier (BBB) significantly restricts systemically delivered therapeutics to brain tumors....

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Andrei Molotkov, Patrick Carberry, Martin A. Dolan, Simon Joseph, Sidney Idumonyi, Shunichi Oya, John Castrillon, Elisa E. Konofagou, Mikhail Doubrovin, Glenn J. Lesser, Francesca Zanderigo, Akiva Mintz
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2021-03-01
Schriftenreihe:	Pharmaceutics
Schlagworte:	blood–brain barrier high-intensity focused ultrasound positron emission tomography topotecan glioblastoma
Online-Zugang:	https://www.mdpi.com/1999-4923/13/3/405
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