Granzyme K mediates IL-23-dependent inflammation and keratinocyte proliferation in psoriasis

Psoriasis is an inflammatory disease with systemic manifestations that most commonly presents as itchy, erythematous, scaly plaques on extensor surfaces. Activation of the IL-23/IL-17 pro-inflammatory signaling pathway is a hallmark of psoriasis and its inhibition is key to clinical management. Gran...

Full description

Bibliographic Details

Main Authors:	Katlyn C. Richardson, Alexandre Aubert, Christopher T. Turner, Layla Nabai, Sho Hiroyasu, Megan A. Pawluk, Rachel A. Cederberg, Hongyan Zhao, Karen Jung, Angela Burleigh, Richard I. Crawford, David J. Granville
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2024-06-01
Series:	Frontiers in Immunology
Subjects:	granzymes granzyme K psoriasis IL-23 PAR-1 inflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1398120/full
Tags:	Add Tag No Tags, Be the first to tag this record!