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Granzyme K mediates IL-23-dependent inflammation and keratinocyte proliferation in psoriasis

Psoriasis is an inflammatory disease with systemic manifestations that most commonly presents as itchy, erythematous, scaly plaques on extensor surfaces. Activation of the IL-23/IL-17 pro-inflammatory signaling pathway is a hallmark of psoriasis and its inhibition is key to clinical management. Gran...

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Autori principali: Katlyn C. Richardson, Alexandre Aubert, Christopher T. Turner, Layla Nabai, Sho Hiroyasu, Megan A. Pawluk, Rachel A. Cederberg, Hongyan Zhao, Karen Jung, Angela Burleigh, Richard I. Crawford, David J. Granville
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2024-06-01
Serie:Frontiers in Immunology
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Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1398120/full
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