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HNRNPC modulates PKM alternative splicing via m6A methylation, upregulating PKM2 expression to promote aerobic glycolysis in papillary thyroid carcinoma and drive malignant progression

Abstract The heterogeneous nuclear ribonucleoprotein C (HNRNPC) plays a crucial role in tumorigenesis, yet its role in papillary thyroid carcinoma (PTC) remains elusive. Herein, we elucidated the function and molecular mechanism of HNRNPC in PTC tumorigenesis and progression. Our study unveiled a si...

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Principais autores: Shikuo Rong, Bao Dai, Chunrong Yang, Ziteng Lan, Linhe Wang, Lei Xu, Weijian Chen, Jian Chen, Zeyu Wu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-10-01
coleção:Journal of Translational Medicine
Assuntos:
Papillary thyroid carcinoma
HNRNPC
PKM
m6A methylation
Glucose metabolism
Acesso em linha:https://doi.org/10.1186/s12967-024-05668-9
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