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KCNJ2/HIF1α positive-feedback loop promotes the metastasis of osteosarcoma

Abstract Background Early metastasis is a hallmark of osteosarcoma (OS), a highly common type of malignant tumor. Members of the potassium inwardly rectifying channel family exert oncogenic effects in various cancers. However, the role of the potassium inwardly rectifying channel subfamily J member...

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Main Authors: Mao Shen, Runsang Pan, Shan Lei, Lu Zhang, Changhua Zhou, Zhirui Zeng, Yingjie Nie, Xiaobin Tian
Format: Artigo
Language:Inglês
Published: BMC 2023-03-01
Series:Cell Communication and Signaling
Subjects:
HIF1α
KCNJ2
Metastasis
Osteosarcoma
Online Access:https://doi.org/10.1186/s12964-023-01064-w
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