Lysine lactylation regulates ATF4-mediated stress responses under glucose starvation in canine hemangiosarcoma

Excess lactate is produced in tumor cells by aerobic glycolysis and regulates gene expressions by histone lactylation. However, how histone lactylation functions under glucose-limited conditions remains unknown. Here, we show that lysine lactylation redistributes to transcription start sites (TSSs)...

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Bibliografische gegevens

Hoofdauteurs:	Tamami Suzuki, Kazuki Heishima, Jumpei Yamazaki, Masaya Yamazaki, Ryohei Kinoshita, Sangho Kim, Kenji Hosoya, Yuko Okamatsu-Ogura, Michihito Sasaki, Peng Xu, Qin Yan, Takashi Kimura, Keisuke Aoshima
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Frontiers Media S.A. 2026-02-01
Reeks:	Frontiers in Veterinary Science
Onderwerpen:	dog glucose hemangiosarcoma histone lactylation stress response tumor metabolism
Online toegang:	https://www.frontiersin.org/articles/10.3389/fvets.2026.1734339/full
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