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Response of Merkel cell polyomavirus-positive merkel cell carcinoma xenografts to a survivin inhibitor.

Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer associated with high mortality. Merkel cell polyomavirus (MCV), discovered in 2008, is associated with ~80% of MCC. The MCV large tumor (LT) oncoprotein upregulates the cellular oncoprotein survivin through its conserved retinoblastoma prot...

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Principais autores: Lindsay R Dresang, Anna Guastafierro, Reety Arora, Daniel Normolle, Yuan Chang, Patrick S Moore
格式: Artigo
語言:Inglês
出版: Public Library of Science (PLoS) 2013-01-01
叢編:PLoS ONE
在線閱讀:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24260412/?tool=EBI
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