Synthetic consensus DNA vaccines against Merkel cell polyomavirus large and small T antigens induce robust polyfunctional T cell responses

Merkel cell carcinoma (MCC) is an aggressive form of skin cancer with a high mortality rate and limited therapeutic options. Approximately 80% of MCC cases are associated with Merkel cell polyomavirus (MCPyV). The Large T antigen (LTAg) and Small T antigen (STAg) of MCPyV are persistently expressed...

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Principais autores:	Pratik S. Bhojnagarwala, Elizabeth K. Duperret, Aspen Trautz, David B. Weiner
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-09-01
Colecção:	Frontiers in Immunology
Assuntos:	DNA vaccination large T antigen Merkel cell carcinoma Merkel cell polyomavirus (MCPyV) small T antigen
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1840943/full
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