CD137+CD154− Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures

Regulatory T cells (Tregs) are an attractive therapeutic tool for several different immune pathologies. Therapeutic Treg application often requires prolonged in vitro culture to generate sufficient Treg numbers or to optimize their functionality, e.g., via genetic engineering of their antigen recept...

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Detalhes bibliográficos

Principais autores:	Anna Nowak, Dominik Lock, Petra Bacher, Thordis Hohnstein, Katrin Vogt, Judith Gottfreund, Pascal Giehr, Julia K. Polansky, Birgit Sawitzki, Andrew Kaiser, Jörn Walter, Alexander Scheffold
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-02-01
coleção:	Frontiers in Immunology
Assuntos:	regulatory T cells chimeric antigen receptor adoptive regulatory T cell therapy regulatory T cell stability regulatory T cell expansion regulatory T cell signaling
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00199/full
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