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Astrocytes sense glymphatic-level shear stress through the interaction of sphingosine-1-phosphate with Piezo1

Summary: Astrocyte endfeet enwrap brain vasculature, forming a boundary for perivascular glymphatic flow of fluid and solutes along and across the astrocyte endfeet into the brain parenchyma. We evaluated astrocyte sensitivity to shear stress generated by such flow, finding a set point for downstrea...

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Principais autores: Antonio Cibelli, David Ballesteros-Gomez, Sean McCutcheon, Greta L. Yang, Ashley Bispo, Michael Krawchuk, Giselle Piedra, David C. Spray
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2024-06-01
Serija:iScience
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Online dostop:http://www.sciencedirect.com/science/article/pii/S258900422401294X
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