SESN2 maintains cartilage homeostasis by SREBP1-mediated lipid metabolism during osteoarthritis progression

Summary: Chondrocytes experience adverse lipid metabolism disorders during the degeneration of cartilage in osteoarthritis (OA), while the underlying mechanisms remain poorly understood. Sestrin2 (SESN2), a highly conserved stress-inducible protein, plays a crucial role in regulating lipid metabolis...

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Hlavní autoři:	Zizheng Liu, Huiming Jiang, Zhaofeng Zhang, Ruiyang Jiang, Rongliang Wang, Jiawei Li, Weitong Li, Guihua Tan, Yuxiang Fei, Zhongyang Lv, Hu Guo, Ziyin Sun, Rui Wu, Hongfei Shi, Dongquan Shi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2025-08-01
Edice:	iScience
Témata:	natural sciences biological sciences biochemistry physiology pathophysiology
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2589004225013586
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