Carriers of Heterozygous Loss-of-Function ACE Mutations Are at Risk for Alzheimer’s Disease

We hypothesized that subjects with heterozygous loss-of-function (LoF) <i>ACE</i> mutations are at risk for Alzheimer’s disease because amyloid Aβ42, a primary component of the protein aggregates that accumulate in the brains of AD patients, is cleaved by ACE (angiotensin I-converting enzyme). Thus,...

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Hlavní autoři:	Sergei M. Danilov, Ivan A. Adzhubei, Alexander J. Kozuch, Pavel A. Petukhov, Isolda A. Popova, Ananyo Choudhury, Dhriti Sengupta, Steven M. Dudek
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2024-01-01
Edice:	Biomedicines
Témata:	angiotensin I-converting enzyme mutations conformational changes plasma <i>ACE</i> screening
On-line přístup:	https://www.mdpi.com/2227-9059/12/1/162
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