Urinary ACE Phenotyping as a Research and Diagnostic Tool: Identification of Sex-Dependent ACE Immunoreactivity

Background: Angiotensin-converting enzyme (ACE) is highly expressed in renal proximal tubules, but ACE activity/levels in the urine are at least 100-fold lower than in the blood. Decreased proximal tubular ACE has been associated with renal tubular damage in both animal models and clinical studies....

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Principais autores:	Alexander J. Kozuch, Pavel A. Petukhov, Miklos Fagyas, Isolda A. Popova, Matthew O. Lindeblad, Alexander P. Bobkov, Armais A. Kamalov, Attila Toth, Steven M. Dudek, Sergei M. Danilov
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2023-03-01
Series:	Biomedicines
Assuntos:	angiotensin I-converting enzyme human urine sex-dependent differences outliers conformational changes glycosylation
Acceso en liña:	https://www.mdpi.com/2227-9059/11/3/953
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