Oridonin induces Mdm2‐p60 to promote p53‐mediated apoptosis and cell cycle arrest in neuroblastoma

Abstract Oridonin could induce NB (neuroblastoma) cells growth inhibition by inducing apoptosis and cell cycle arrest, and the molecular mechanisms behind the effects deserve to be further explored. Here, oridonin was confirmed to cause the reactivation of p53 (cellular tumor antigen p53) to promote...

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Detalhes bibliográficos

Principais autores:	Han‐Qing Zhu, Chao Zhang, Zhu‐Ying Guo, Jun‐Mei Yang, Jia‐Hui Guo, Chen Chen, Qiang‐Hua Yao, Feng Liu, Quan‐Wu Zhang, Feng‐Hou Gao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2019-09-01
coleção:	Cancer Medicine
Assuntos:	apoptosis cell cycle arrest Mdm2‐p60 Oridonin p53 ROS
Acesso em linha:	https://doi.org/10.1002/cam4.2393
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