Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs.

We have successfully established and characterized a genetically modified pig line with ubiquitous expression of LEA29Y, a human CTLA4-Ig derivate. LEA29Y binds human B7.1/CD80 and B7.2/CD86 with high affinity and is thus a potent inhibitor of T cell co-stimulation via this pathway. We have characte...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Andrea Bähr, Tobias Käser, Elisabeth Kemter, Wilhelm Gerner, Mayuko Kurome, Wiebke Baars, Nadja Herbach, Kirsti Witter, Annegret Wünsch, Stephanie C Talker, Barbara Kessler, Hiroshi Nagashima, Armin Saalmüller, Reinhard Schwinzer, Eckhard Wolf, Nikolai Klymiuk
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Public Library of Science (PLoS) 2016-01-01
سلاسل:	PLoS ONE
الوصول للمادة أونلاين:	http://europepmc.org/articles/PMC4866763?pdf=render
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!