What Genetic Modifications of Source Pigs Are Essential and Sufficient for Cell, Tissue, and Organ Xenotransplantation?

Xenotransplantation of porcine organs has made remarkable progress towards clinical application. A key factor has been the generation of genetically multi-modified source pigs for xenotransplants, protected against immune rejection and coagulation dysregulation. While efficient gene editing tools an...

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Principais autores:	Asghar Ali, Mayuko Kurome, Barbara Kessler, Elisabeth Kemter, Eckhard Wolf
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2024-12-01
coleção:	Transplant International
Assuntos:	pig genetic modification xeno-antigens complement activation coagulation dysregulation
Acesso em linha:	https://www.frontierspartnerships.org/articles/10.3389/ti.2024.13681/full
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