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Rapid and sustained T cell-based immunotherapy against invasive fungal disease via a combined two step procedure

IntroductionAspergillus fumigatus (Asp) infections constitute a major cause of morbidity and mortality in patients following allogeneic hematopoietic stem cell transplantation (HSCT). In the context of insufficient host immunity, antifungal drugs show only limited efficacy. Faster and increased T-ce...

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Main Authors: Sabine Tischer-Zimmermann, Elisabeth Salzer, Tamires Bitencourt, Nelli Frank, Christine Hoffmann-Freimüller, Julia Stemberger, Britta Maecker-Kolhoff, Rainer Blasczyk, Volker Witt, Gerhard Fritsch, Wolfgang Paster, Thomas Lion, Britta Eiz-Vesper, René Geyeregger
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
HSCT
Aspergillus infections
T-cell immunotherapy
Aspergillus-specific T cells
T-cell expansion
cytokine secretion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.988947/full
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