Accelerated response and reduced chemotherapy with ruxolitinib-based regimen therapy in pediatric hemophagocytic lymphohistiocytosis: a retrospective comparison with HLH-94 regimen

ObjectiveTo compare the efficacy of a Ruxolitinib-based regimen versus the conventional HLH-94 protocol in children with newly diagnosed hemophagocytic lymphohistiocytosis (HLH).MethodsThis single-center, retrospective historical control study enrolled 67 pediatric HLH patients who met the HLH-2004...

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Autores principales:	Na Song, Haiyan Luo, Benshan Zhang, Pan Wu, Xiaoqin Zhang, Qianxiu Fan, Huimin Xu, Zilin Gong, Chenli Zhou, Shiyi Hu, Xinping Zhang, Jiaotian Huang, Haixia Yang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2026-03-01
Colección:	Frontiers in Immunology
Materias:	chemotherapy reduction children efficacy hemophagocytic lymphohistiocytosis retrospective study ruxolitinib
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1769006/full
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