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Accelerated response and reduced chemotherapy with ruxolitinib-based regimen therapy in pediatric hemophagocytic lymphohistiocytosis: a retrospective comparison with HLH-94 regimen

ObjectiveTo compare the efficacy of a Ruxolitinib-based regimen versus the conventional HLH-94 protocol in children with newly diagnosed hemophagocytic lymphohistiocytosis (HLH).MethodsThis single-center, retrospective historical control study enrolled 67 pediatric HLH patients who met the HLH-2004...

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Principais autores: Na Song, Haiyan Luo, Benshan Zhang, Pan Wu, Xiaoqin Zhang, Qianxiu Fan, Huimin Xu, Zilin Gong, Chenli Zhou, Shiyi Hu, Xinping Zhang, Jiaotian Huang, Haixia Yang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-03-01
Serier:Frontiers in Immunology
Fag:
chemotherapy reduction
children
efficacy
hemophagocytic lymphohistiocytosis
retrospective study
ruxolitinib
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1769006/full
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