Deletion Mutants of <i>Francisella</i> Phagosomal Transporters FptA and FptF Are Highly Attenuated for Virulence and Are Protective Against Lethal Intranasal <i>Francisella</i> LVS Challenge in a Murine Model of Respiratory Tularemia

<i>Francisella tularensis</i> (<i>Ft</i>) is a Gram-negative, facultative intracellular bacterium that is a Tier 1 Select Agent of concern for biodefense for which there is no licensed vaccine. A subfamily of 9 <i>Francisella</i> phagosomal transporter (<i>fpt</i>) genes belonging to the Major Facil...

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Principais autores:	Brandi E. Hobbs, Courtney A. Matson, Vasileios I. Theofilou, Tonya J. Webb, Rania H. Younis, Eileen M. Barry
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-06-01
coleção:	Pathogens
Assuntos:	<i>Francisella tularensis</i> Live Vaccine Strain (LVS) live attenuated vaccine MFS transporter attenuation organ burdens
Acesso em linha:	https://www.mdpi.com/2076-0817/10/7/799
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