MT5-MMP promotes neuroinflammation, neuronal excitability and Aβ production in primary neuron/astrocyte cultures from the 5xFAD mouse model of Alzheimer’s disease

Abstract Background Membrane-type matrix metalloproteinase 5 (MT5-MMP) deficiency in the 5xFAD mouse model of Alzheimer's disease (AD) reduces brain neuroinflammation and amyloidosis, and prevents deficits in synaptic activity and cognition in prodromal stages of the disease. In addition, MT5-MMP de...

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Автори:	Dominika Pilat, Jean-Michel Paumier, Laura García-González, Laurence Louis, Delphine Stephan, Christine Manrique, Michel Khrestchatisky, Eric Di Pasquale, Kévin Baranger, Santiago Rivera
Формат:	Artigo
Мова:	Inglês
Опубліковано:	BMC 2022-03-01
Серія:	Journal of Neuroinflammation
Предмети:	Neuroinflammation IL-1β Amyloid peptide Amyloid precursor protein C99 Synaptic activity
Онлайн доступ:	https://doi.org/10.1186/s12974-022-02407-z
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