Neuroprotective role of MMP-9 overexpression in the brain of Alzheimer's 5xFAD mice
Accumulation of amyloid-β (Αβ) peptide is believed to play a central role in the pathogenesis of Alzheimer's disease (AD). Lowering Aβ levels in the brain may thus improve synaptic and cognitive deficits observed in AD patients. In the non-amyloidogenic pathway, the amyloid-β precursor protein (APP)...
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| Principais autores: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2014-10-01
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| Serier: | Neurobiology of Disease |
| Fag: | |
| Online adgang: | http://www.sciencedirect.com/science/article/pii/S0969996114001855 |
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